NAD+:
Dosage, Benefits,
and Research Explained
NAD+ (Nicotinamide Adenine Dinucleotide) is a vital coenzyme found in every cell of the body, playing a key role in energy metabolism, DNA repair, and cellular aging. As we age, NAD+ levels decline, leading to fatigue, cognitive decline, reduced metabolic function, and increased inflammation.
By replenishing NAD+ levels, individuals may experience enhanced energy, improved brain function, increased longevity, and better overall cellular health.
NAD+ supplementation has been widely studied for anti-aging, neuroprotection, and metabolic health, making it a cornerstone of longevity and biohacking medicine.
Nicotinamide Adenine Dinucleotide
CAS Number: 53-84-9
Formula: C21H27N7O14P1
| Purpose | Dosage | Frequency |
|---|---|---|
| Energy/ Athletic Performance |
500-1,000 mg | Once Daily |
| Cognitive/ Anti-Aging |
1 mg Daily | Once Daily |
How It Works
NAD+ functions as a crucial coenzyme in cellular metabolism, supporting:
✔ Energy production (ATP synthesis) in mitochondria
✔ Sirtuin activation, promoting longevity and DNA repair
✔ Cognitive function and neuroprotection
✔ Inflammation reduction and cellular detoxification
✔ Improved metabolism and weight management
NAD+ declines with age, which can contribute to chronic fatigue, brain fog, and metabolic disorders. Restoring NAD+ levels rejuvenates cells, enhances energy production, and slows the aging process.
Research-Backed Benefits
1. Increased Energy & Mitochondrial Function
- NAD+ is essential for ATP production, helping to combat fatigue and enhance endurance.
- Used by athletes and biohackers to boost physical and mental performance.
2. Cognitive Function & Neuroprotection
- NAD+ supports neuronal repair and protection, improving memory, focus, and mental clarity.
- Shown to be beneficial in neurodegenerative conditions like Alzheimer’s and Parkinson’s disease.
3. Anti-Aging & Longevity
- NAD+ activates sirtuins (SIRT1 & SIRT3), which regulate DNA repair, inflammation control, and cellular health.
- Increasing NAD+ levels slows down age-related decline and extends healthspan.
4. Metabolic & Weight Management Benefits
- NAD+ enhances insulin sensitivity and fat oxidation, making it useful for weight loss and metabolic disorders.
- Plays a role in glucose regulation and overall metabolic health.
5. Detoxification & Inflammation Reduction
- Helps reduce oxidative stress and inflammation, supporting immune function and tissue repair.
Conclusion
NAD+ is a foundational molecule for cellular health, energy production, and longevity. By restoring NAD+ levels, individuals can experience increased energy, improved brain function, enhanced metabolism, and anti-aging benefits. Whether used as oral supplementation, IV therapy, or in combination with other longevity strategies, NAD+ is a powerful tool for optimizing health and extending lifespan.
Disclaimer
This product is for research and educational purposes only. It is not FDA-approved for medical use, diagnosis, or treatment. Always consult a healthcare professional before use.
What is NAD+
Nicotinamide adenine dinucleotide (NAD+) is a vital coenzyme present in every cell of the human body. It plays a crucial role in energy metabolism, DNA repair, and cellular communication. As we age, NAD+ levels naturally decline, which can contribute to various age-related health issues.
How does NAD+ therapy work?
NAD+ therapy involves administering NAD+ directly into the bloodstream, typically through intravenous (IV) infusions or subcutaneous injections. This method bypasses the digestive system, allowing for more efficient absorption and utilization by the body’s cells. By replenishing NAD+ levels, the therapy aims to restore cellular function and promote overall health.
What Are the Benefits of NAD+ Therapy?
NAD+ therapy has been associated with several potential benefits, including:
Enhanced Energy Levels: By boosting cellular metabolism, NAD+ can help increase overall energy.
Improved Cognitive Function: Supports brain health, potentially enhancing focus, clarity, and memory.
Anti-Aging Effects: May slow down the aging process by promoting DNA repair and reducing oxidative stress.
Metabolic Support: Assists in weight management and metabolic function.
Mood Enhancement: Can help alleviate symptoms of depression and anxiety by supporting neurotransmitter function.
Addiction Recovery Support: May reduce cravings and withdrawal symptoms during recovery processes.
Is NAD+ safe?
NAD+ therapy is generally considered safe when administered under medical supervision. Some individuals may experience mild side effects, such as nausea, headache, or fatigue, particularly if the infusion is administered too rapidly. Adjusting the infusion rate often mitigates these effects.
Referenced Citations
- Poljšak B, Kovač V, Milisav I. Current Uncertainties and Future Challenges Regarding NAD+ Boosting Strategies. Antioxidants. 2022; 11(9):1638. [Online].
Available: https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9495723/ - Gilmour BC, et al. The Role of NAD+ in Regenerative Medicine. Cells. 2022; 11(19):3057. [Online].
Available: https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9512238/ - Mehmel M, et al. NAD+ Metabolism in Cardiac Health, Aging, and Disease. Circulation. 2021; 144(22):1795-1817. [Online].
Available: https://www.ahajournals.org/doi/full/10.1161/CIRCULATIONAHA.121.056589 - Covarrubias AJ, et al. NAD+ metabolism and its roles in cellular processes during ageing. Nat Rev Mol Cell Biol. 2021; 22(2):119-141. [Online].
Available: https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7963035/ - Sultani G, et al. NAD+: a key metabolic regulator with great therapeutic potential. J Neuroendocrinol. 2017; 29(10):e12508. [Online].
Available: https://pubmed.ncbi.nlm.nih.gov/28580642/