Mots-c

MOTS-C

Dosage, Benefits,

and Research Explained

MOTS-c is a mitochondrial-derived peptide (MDP) that plays a crucial role in metabolism, energy regulation, and cellular longevity. Unlike traditional peptides, MOTS-c is unique because it is encoded by mitochondrial DNA (mtDNA) rather than nuclear DNA. This allows it to directly influence energy production, insulin sensitivity, and cellular resilience.

As a cutting-edge longevity peptide, MOTS-c is used by biohackers, athletes, and those looking to optimize metabolism and cellular health.

Mitochondrial-derived

CAS Number: 1627580-64-6

Formula: C10H152N28O22S2

Purchase

Purchase from our preferred vendor: Project Zero

Purpose Dosage Frequency
Metabolic /
Fat Loss		 5-10 mg Weekly Once Weekly
Energy /
Athletic Performance		 5-15 mg Weekly Once Weekly

How It Works

MOTS-c enhances mitochondrial function and energy metabolism by:

✔ Activating AMPK (AMP-activated protein kinase) – Promotes fat burning & cellular energy regulation.
✔ Improving insulin sensitivity – Supports glucose uptake & metabolic balance.
✔ Enhancing mitochondrial biogenesis – Boosts cellular energy production & repair.
✔ Increasing stress resistance – Protects cells from oxidative damage & aging.

Unlike other metabolic peptides (like Semaglutide or Tesamorelin), MOTS-c works at the mitochondrial level, making it one of the most potent energy-enhancing peptides available.

 

Research-Backed Benefits

1. Metabolic Optimization & Fat Loss

  • MOTS-c activates AMPK, a key metabolic enzyme that helps burn fat and regulate energy balance.
  • Increases glucose uptake & insulin sensitivity, making it effective for fat loss & metabolic health.

2. Increased Energy & Endurance

  • Boosts mitochondrial function, leading to higher energy levels & better physical performance.
  • Used by athletes & endurance trainers to improve stamina & recovery.

3. Insulin Sensitivity & Blood Sugar Control

  • Enhances glucose metabolism, helping regulate insulin resistance & type 2 diabetes.
  • Supports better carbohydrate utilization & reduced glucose spikes.

4. Longevity & Cellular Protection

  • Activates cellular repair mechanisms, reducing oxidative stress & DNA damage.
  • Helps counteract aging effects by improving mitochondrial efficiency & stress resilience.

5. Cognitive & Neurological Support

  • MOTS-c’s effects on mitochondrial health may improve brain energy metabolism & cognitive function.
  • Shows potential for neuroprotection & mental clarity enhancement.

 

Conclusion

MOTS-c is a powerful mitochondrial peptide that supports energy production, metabolic health, and longevity. By activating AMPK and improving mitochondrial function, it helps burn fat, boost endurance, regulate glucose, and slow aging.

Unlike traditional weight loss peptides, MOTS-c offers sustained cellular benefits, making it one of the most cutting-edge biohacking tools for metabolic health and longevity.

 

Disclaimer

This product is for research and educational purposes only. It is not FDA-approved for medical use, diagnosis, or treatment. Always consult a healthcare professional before use.

How is MOTS-c different from other metabolic peptides like Semaglutide or Tesamorelin?

✔ MOTS-c works at the mitochondrial level, whereas GLP-1 agonists (like Semaglutide) act on appetite regulation.
✔ MOTS-c increases energy & endurance, while Tesamorelin primarily boosts HGH levels for fat loss.
✔ MOTS-c is a longevity peptide, providing anti-aging & metabolic benefits beyond fat loss.

  • Energy boost & endurance: Within 1-2 weeks.
  • Fat loss & metabolism improvement: Noticeable within 4-6 weeks.
  • Longevity & mitochondrial repair: Benefits accumulate over months of use.

MOTS-c is well-tolerated, with minimal reported side effects. Possible mild effects include:
✔ Temporary fatigue (in some users after injection)
✔ Mild injection site irritation
✔ Slight increase in body temperature or warmth

Tip: If experiencing post-injection fatigue, try lowering the dose or taking it in the morning instead of at night.

Yes! Popular stacks for enhanced benefits include:
✔ NAD+ or NR/NMN – For longevity & mitochondrial synergy.
✔ Tesamorelin or CJC-1295 – For metabolic health & fat loss optimization.
✔ Resveratrol & Metformin – For AMPK activation & anti-aging effects.

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