/* peptideinfo.org
   Layout: a reference library in black, gray and white. Light gray ground, white panels,
   near-black type and buttons, mono eyebrows for data labels, display face for headings.
   Content column max 760px for reading, wider grids for reference tables. Panels stack under 900px.
   The only color left on the page is functional: green/amber/red for status and warnings. */
:root {
  --bg: #F4F4F5;
  --surface: #FFFFFF;
  --surface-2: #EAEAEC;
  --fg: #111113;
  --muted: #5F6167;
  --line: #D6D6DA;
  --accent: #1C1C1F;
  --accent-ink: #000000;
  --accent-soft: #E6E6E9;
  --on-accent: #FFFFFF;
  --fluid: #6E6E74;
  --good: #2E7D4F;
  --warn: #A8701A;
  --bad: #BE3A3A;
  --header-bg: #111113;
  --header-fg: #FFFFFF;
  --header-muted: #B9B9BF;
  --header-hover: rgba(255, 255, 255, .12);
  --font-display: 'Bricolage Grotesque', 'Segoe UI', system-ui, sans-serif;
  --font-body: 'IBM Plex Sans', 'Segoe UI', system-ui, sans-serif;
  --font-mono: 'IBM Plex Mono', ui-monospace, 'SF Mono', Menlo, Consolas, monospace;
  --measure: 68ch;
  --gutter: 20px;
  color-scheme: light;
}
@media (prefers-color-scheme: dark) {
  :root:not([data-theme="light"]) {
    --bg: #0F0F10; --surface: #18181A; --surface-2: #232326; --fg: #F1F1F2; --muted: #A2A2A8; --line: #313135;
    --accent: #F1F1F2; --accent-ink: #FFFFFF; --accent-soft: #2A2A2E; --on-accent: #111113; --fluid: #B4B4BA;
    --good: #5CC68E; --warn: #E2AA4C; --bad: #F07474;
    --header-bg: #000000; --header-fg: #FFFFFF; --header-muted: #B9B9BF; --header-hover: rgba(255, 255, 255, .14); color-scheme: dark;
  }
}
:root[data-theme="dark"] {
  --bg: #0F0F10; --surface: #18181A; --surface-2: #232326; --fg: #F1F1F2; --muted: #A2A2A8; --line: #313135;
  --accent: #F1F1F2; --accent-ink: #FFFFFF; --accent-soft: #2A2A2E; --on-accent: #111113; --fluid: #B4B4BA;
  --good: #5CC68E; --warn: #E2AA4C; --bad: #F07474;
  --header-bg: #000000; --header-fg: #FFFFFF; --header-muted: #B9B9BF; --header-hover: rgba(255, 255, 255, .14); color-scheme: dark;
}

*, *::before, *::after { box-sizing: border-box; }
[hidden] { display: none !important; }
html { -webkit-text-size-adjust: 100%; scroll-behavior: smooth; }
@media (prefers-reduced-motion: reduce) { html { scroll-behavior: auto; } }
body { margin: 0; background: var(--bg); color: var(--fg); font-family: var(--font-body); font-size: 16px; line-height: 1.55; }
img, svg { max-width: 100%; }
a { color: var(--accent-ink); text-decoration-thickness: 1px; text-underline-offset: 2px; }
a:hover { color: var(--accent); }
:focus-visible { outline: 2px solid var(--accent); outline-offset: 2px; }
h1, h2, h3, h4 { font-family: var(--font-display); letter-spacing: -.01em; line-height: 1.12; margin: 0; text-wrap: balance; }
h1 { font-size: clamp(32px, 5vw, 48px); font-weight: 800; letter-spacing: -.02em; }
h2 { font-size: clamp(22px, 3vw, 28px); font-weight: 700; }
h3 { font-size: 18px; font-weight: 700; }
p { margin: 0 0 1em; }
p:last-child { margin-bottom: 0; }
.eyebrow { font-family: var(--font-mono); font-size: 12px; letter-spacing: .08em; text-transform: uppercase; color: var(--muted); }
.muted { color: var(--muted); }
.wrap { max-width: 1120px; margin: 0 auto; padding-inline: var(--gutter); }
.prose { max-width: var(--measure); }
.prose p { font-size: 17px; }
.tnum { font-variant-numeric: tabular-nums; }

/* header */
.site-header { background: var(--header-bg); color: var(--header-fg); position: sticky; top: env(safe-area-inset-top, 0px); z-index: 5; }
.site-header .wrap { display: flex; align-items: center; justify-content: space-between; gap: 16px; min-height: 60px; flex-wrap: wrap; padding-block: 8px; }
.brand { display: flex; align-items: center; gap: 10px; text-decoration: none; color: var(--header-fg); font-family: var(--font-display); font-weight: 800; font-size: 19px; letter-spacing: -.01em; }
.brand::before { content: ""; width: 12px; height: 12px; border-radius: 50%; background: var(--header-fg); flex: none; }
.brand span { color: var(--header-muted); font-weight: 500; font-family: var(--font-mono); font-size: 12px; letter-spacing: .08em; text-transform: uppercase; margin-left: 4px; }
.nav { display: flex; align-items: center; gap: 4px; flex-wrap: wrap; }
.nav a, .nav summary { display: inline-block; padding: 7px 10px; border-radius: 7px; text-decoration: none; color: var(--header-fg); font-weight: 500; font-size: 14.5px; cursor: pointer; list-style: none; }
.nav summary::-webkit-details-marker { display: none; }
.nav a:hover, .nav summary:hover, .nav a[aria-current="page"] { background: var(--header-hover); color: var(--header-fg); }
.nav a[aria-current="page"] { font-weight: 600; }
.nav details { position: relative; }
.nav details[open] summary { background: var(--header-hover); }
.nav .menu { position: absolute; right: 0; top: calc(100% + 6px); background: var(--surface); border: 1px solid var(--line); border-radius: 10px; padding: 8px; min-width: 240px; box-shadow: 0 14px 40px rgba(0, 0, 0, .22); display: grid; gap: 2px; z-index: 6; }
.nav .menu a { display: block; padding: 8px 10px; font-weight: 500; color: var(--fg); }
.nav .menu a:hover { background: var(--surface-2); color: var(--fg); }
.nav .menu a small { display: block; color: var(--muted); font-weight: 400; font-size: 12px; }
.nav .cta, .nav .cta[aria-current="page"] { background: var(--header-fg); color: var(--header-bg); font-weight: 600; }
.nav .cta:hover { background: var(--header-muted); color: var(--header-bg); }
.site-header:focus-within, .site-header :focus-visible { outline-color: var(--header-fg); }
@media (max-width: 640px) { .nav .menu { right: auto; left: 0; } .brand span { display: none; } }

/* partner bar (under the header, every page) */
.partner-bar { background: var(--surface); border-bottom: 1px solid var(--line); font-size: 13.5px; color: var(--muted); }
.partner-bar .wrap { display: flex; align-items: center; justify-content: center; gap: 6px 14px; flex-wrap: wrap; min-height: 38px; padding-block: 6px; text-align: center; }
.partner-bar strong { color: var(--fg); font-weight: 600; }
.partner-bar a { color: var(--fg); font-weight: 600; text-decoration: underline; text-underline-offset: 3px; white-space: nowrap; }
.partner-bar a:hover { color: var(--muted); }

/* partner product card (peptide pages) */
.partner { display: grid; grid-template-columns: 180px minmax(0, 1fr); gap: 22px; align-items: center; background: var(--surface); border: 1px solid var(--line); border-radius: 14px; padding: 20px; margin-top: 28px; }
.partner img { width: 100%; height: auto; aspect-ratio: 1 / 1; border-radius: 10px; display: block; background: #000; object-fit: cover; }
.partner h2 { font-size: 21px; margin: 4px 0 8px; }
.partner p { margin: 0 0 8px; font-size: 15px; color: var(--muted); }
.partner .partner-actions { display: flex; gap: 10px; flex-wrap: wrap; align-items: center; margin: 12px 0 10px; }
.partner .also { font-size: 13.5px; }
.partner .also a { color: var(--fg); }
.partner .note { font-size: 12.5px; margin: 0; }
@media (max-width: 640px) { .partner { grid-template-columns: 1fr; } .partner img { max-width: 220px; } }

/* partner promo (home) */
.partner-promo { border: 1px solid var(--header-hover); display: grid; grid-template-columns: minmax(0, 1fr) auto; gap: 18px; align-items: center; background: var(--header-bg); color: var(--header-fg); border-radius: 14px; padding: 24px 26px; }
.partner-promo h2 { color: var(--header-fg); }
.partner-promo p { margin: 8px 0 0; color: var(--header-muted); }
.partner-promo .btn { background: var(--header-fg); border-color: var(--header-fg); color: var(--header-bg); }
.partner-promo .btn:hover { background: var(--header-muted); border-color: var(--header-muted); color: var(--header-bg); }
@media (max-width: 700px) { .partner-promo { grid-template-columns: 1fr; } }

/* page frame */
main { padding-block: 32px 56px; }
.page-head { display: grid; gap: 12px; margin-bottom: 26px; max-width: 820px; }
.crumbs { font-size: 13px; color: var(--muted); display: flex; gap: 6px; flex-wrap: wrap; }
.crumbs a { color: var(--muted); text-decoration: none; }
.crumbs a:hover { color: var(--accent-ink); text-decoration: underline; }
.crumbs span::before { content: "/"; margin-right: 6px; opacity: .6; }
.lede { font-size: 18px; color: var(--muted); max-width: 64ch; margin: 0; }
.chips { display: flex; gap: 8px; flex-wrap: wrap; }
.chip { display: inline-flex; align-items: center; gap: 6px; padding: 4px 10px; border-radius: 999px; font-size: 12.5px; font-weight: 500; border: 1px solid var(--line); color: var(--muted); text-decoration: none; background: var(--surface); }
.chip.tag { background: var(--accent-soft); border-color: transparent; color: var(--accent-ink); font-family: var(--font-mono); font-size: 11.5px; letter-spacing: .04em; text-transform: uppercase; }
a.chip:hover { border-color: var(--accent); color: var(--accent-ink); }

/* sections */
.section { margin-top: 40px; }
.section > h2 { margin-bottom: 14px; }
.section-head { display: flex; align-items: baseline; justify-content: space-between; gap: 12px; flex-wrap: wrap; margin-bottom: 14px; }
.section-head p { color: var(--muted); margin: 0; font-size: 14.5px; }
.panel { background: var(--surface); border: 1px solid var(--line); border-radius: 12px; padding: 22px; min-width: 0; }
.two-col { display: grid; grid-template-columns: minmax(0, 7fr) minmax(0, 5fr); gap: 20px; align-items: start; }
@media (max-width: 900px) { .two-col { grid-template-columns: 1fr; } }

.facts { display: grid; grid-template-columns: repeat(auto-fit, minmax(200px, 1fr)); gap: 14px 22px; margin: 0; }
.facts > div { border-top: 1px solid var(--line); padding-top: 10px; min-width: 0; }
.facts dt { font-family: var(--font-mono); font-size: 11px; letter-spacing: .08em; text-transform: uppercase; color: var(--muted); }
.facts dd { margin: 4px 0 0; font-size: 15px; line-height: 1.45; }

.cards { display: grid; grid-template-columns: repeat(auto-fit, minmax(240px, 1fr)); gap: 14px; }
.card { background: var(--surface); border: 1px solid var(--line); border-radius: 12px; padding: 18px; min-width: 0; display: grid; gap: 8px; align-content: start; }
.card h3 { font-size: 16.5px; }
.card p { font-size: 14.5px; color: var(--muted); margin: 0; }
.card .year { font-family: var(--font-mono); font-size: 12px; color: var(--accent-ink); letter-spacing: .04em; }
.card .refs { font-size: 12px; }
.card .refs a { text-decoration: none; font-family: var(--font-mono); }
.card.link { text-decoration: none; color: inherit; transition: border-color .15s; }
.card.link:hover { border-color: var(--accent); }
.card.link h3 { color: var(--accent-ink); }
.findings { display: grid; grid-template-columns: repeat(auto-fit, minmax(240px, 1fr)); gap: 0 28px; }
.findings > div { padding: 14px 0; border-top: 1px solid var(--line); }
.findings h3 { font-size: 16px; margin-bottom: 4px; }
.findings p { font-size: 14.5px; color: var(--muted); margin: 0; }

.protocols { display: grid; gap: 12px; margin: 0; }
.protocols > div { display: grid; grid-template-columns: 200px minmax(0, 1fr); gap: 4px 18px; padding: 12px 0; border-top: 1px solid var(--line); }
.protocols dt { font-weight: 600; font-size: 15px; }
.protocols dd { margin: 0; font-size: 15px; color: var(--muted); }
@media (max-width: 640px) { .protocols > div { grid-template-columns: 1fr; } }
.scroll { overflow-x: auto; }
table { border-collapse: collapse; width: 100%; font-size: 14px; font-variant-numeric: tabular-nums; background: var(--surface); }
th, td { text-align: left; padding: 10px 12px; border-bottom: 1px solid var(--line); vertical-align: top; }
th { font-family: var(--font-mono); font-size: 11px; letter-spacing: .06em; text-transform: uppercase; color: var(--muted); font-weight: 500; white-space: nowrap; background: var(--surface-2); }
td:first-child { font-weight: 600; white-space: nowrap; }
td.notes { color: var(--muted); min-width: 220px; }
.table-wrap { border: 1px solid var(--line); border-radius: 10px; overflow: hidden; }
.note { font-size: 13.5px; color: var(--muted); }
.callout { display: flex; gap: 14px; align-items: flex-start; background: var(--accent-soft); border-radius: 10px; padding: 14px 16px; color: var(--accent-ink); }
.callout p { margin: 0; font-size: 14.5px; }
.callout a { font-weight: 600; }
.callout::before { content: ""; width: 10px; height: 10px; border-radius: 50%; background: var(--accent); flex: none; margin-top: 7px; }

.refs-list { list-style: none; margin: 0; padding: 0; display: grid; gap: 10px; counter-reset: ref; }
.refs-list li { display: grid; grid-template-columns: 34px minmax(0, 1fr); gap: 10px; padding: 10px 0; border-top: 1px solid var(--line); font-size: 14.5px; }
.refs-list li .n { font-family: var(--font-mono); color: var(--muted); font-size: 13px; padding-top: 2px; }
.refs-list .cite { font-weight: 600; }
.refs-list .links { display: flex; gap: 12px; flex-wrap: wrap; font-family: var(--font-mono); font-size: 12.5px; margin-top: 4px; }
.refs-list .pending { display: inline-block; font-family: var(--font-mono); font-size: 11.5px; letter-spacing: .04em; text-transform: uppercase; color: var(--warn); border: 1px solid currentColor; border-radius: 999px; padding: 2px 8px; margin-top: 4px; }

.safety { display: grid; grid-template-columns: repeat(auto-fit, minmax(240px, 1fr)); gap: 14px; }
.safety .card h3 { font-size: 15.5px; }
.disclaimer { margin-top: 40px; padding: 18px 20px; border: 1px solid var(--line); border-radius: 12px; background: var(--surface); }
.disclaimer h2 { font-size: 16px; margin-bottom: 8px; }
.disclaimer p { font-size: 13.5px; color: var(--muted); }
.highlights { display: grid; grid-template-columns: repeat(auto-fit, minmax(200px, 1fr)); gap: 14px; margin-top: 18px; }
.highlights > div { background: var(--surface-2); border-radius: 10px; padding: 14px 16px; }
.highlights h3 { font-size: 15px; margin-bottom: 4px; }
.highlights p { margin: 0; font-size: 13.5px; color: var(--muted); }
.related { display: flex; gap: 8px; flex-wrap: wrap; }

.meta-line { display: flex; gap: 14px; flex-wrap: wrap; font-family: var(--font-mono); font-size: 12px; color: var(--muted); letter-spacing: .03em; }

/* home */
.hero { padding-block: 24px 8px; display: grid; gap: 16px; max-width: 800px; }
.hero h1 { font-size: clamp(36px, 6vw, 60px); line-height: 1.0; }
.hero .lede { font-size: 19px; }
.hero .actions { display: flex; gap: 10px; flex-wrap: wrap; }
.btn { display: inline-block; border: 1px solid var(--accent); background: var(--accent); color: var(--on-accent); font: 600 15px var(--font-body); padding: 11px 18px; border-radius: 8px; cursor: pointer; text-decoration: none; }
.btn:hover { background: var(--accent-ink); border-color: var(--accent-ink); color: var(--on-accent); }
.btn.ghost { background: transparent; color: var(--accent-ink); }
.btn.ghost:hover { background: var(--accent-soft); }
.cat-grid { display: grid; grid-template-columns: repeat(auto-fit, minmax(280px, 1fr)); gap: 14px; }
.cat-card { background: var(--surface); border: 1px solid var(--line); border-radius: 12px; padding: 18px; display: grid; gap: 10px; align-content: start; min-width: 0; }
.cat-card h3 a { text-decoration: none; color: var(--fg); }
.cat-card h3 a:hover { color: var(--accent-ink); }
.cat-card p { margin: 0; font-size: 14px; color: var(--muted); }
.cat-card ul { list-style: none; margin: 0; padding: 0; display: flex; gap: 6px; flex-wrap: wrap; }
.cat-card ul a { display: inline-block; padding: 4px 10px; border-radius: 999px; border: 1px solid var(--line); text-decoration: none; font-size: 13px; color: var(--fg); background: var(--surface); }
.cat-card ul a:hover { border-color: var(--accent); color: var(--accent-ink); }
.cat-card .count { font-family: var(--font-mono); font-size: 11.5px; letter-spacing: .06em; text-transform: uppercase; color: var(--accent-ink); }
.method { display: grid; grid-template-columns: repeat(auto-fit, minmax(240px, 1fr)); gap: 18px 24px; }
.method h3 { font-size: 16px; margin-bottom: 6px; }
.method p { margin: 0; font-size: 14.5px; color: var(--muted); }
.promo { display: grid; grid-template-columns: minmax(0, 1fr) auto; gap: 18px; align-items: center; background: var(--surface); border: 1px solid var(--line); border-radius: 14px; padding: 22px 24px; }
.promo p { margin: 0; color: var(--muted); }
@media (max-width: 700px) { .promo { grid-template-columns: 1fr; } }

/* index lists */
.index { display: grid; gap: 0; }
.index a { display: grid; grid-template-columns: minmax(0, 1fr) auto; gap: 12px; align-items: baseline; padding: 14px 0; border-top: 1px solid var(--line); text-decoration: none; color: inherit; }
.index a:last-child { border-bottom: 1px solid var(--line); }
.index a:hover strong { color: var(--accent-ink); }
.index strong { font-family: var(--font-display); font-size: 18px; }
.index small { display: block; color: var(--muted); font-size: 14px; margin-top: 2px; }
.index .cat { font-family: var(--font-mono); font-size: 11.5px; letter-spacing: .06em; text-transform: uppercase; color: var(--muted); white-space: nowrap; }
@media (max-width: 560px) { .index a { grid-template-columns: 1fr; } }

/* legal pages */
.legal h2 { font-size: 20px; margin-top: 28px; margin-bottom: 8px; }
.legal p, .legal li { font-size: 15.5px; }
.legal ul { padding-left: 20px; }

/* footer */
.site-footer { border-top: 1px solid var(--line); background: var(--surface); padding-block: 28px 40px; font-size: 13.5px; color: var(--muted); }
.site-footer .wrap { display: grid; grid-template-columns: minmax(0, 2fr) minmax(0, 1fr) minmax(0, 1fr); gap: 24px; }
@media (max-width: 760px) { .site-footer .wrap { grid-template-columns: 1fr; } }
.site-footer h4 { font-family: var(--font-mono); font-size: 11.5px; letter-spacing: .08em; text-transform: uppercase; color: var(--muted); margin: 0 0 8px; }
.site-footer ul { list-style: none; margin: 0; padding: 0; display: grid; gap: 6px; }
.site-footer a { color: var(--fg); text-decoration: none; }
.site-footer a:hover { color: var(--accent-ink); text-decoration: underline; }
.site-footer .legal-line { grid-column: 1 / -1; border-top: 1px solid var(--line); padding-top: 14px; font-size: 12.5px; }