VIP

VIP:

Dosage, Benefits,

and Research Explained

VIP, or Vasoactive Intestinal Peptide, is a naturally occurring neuropeptide that plays a vital role in regulating numerous physiological processes. This synthetic version of VIP is being explored for its potential in supporting vasodilation, neuroprotection, and immune modulation, making it a fascinating subject for research into various health conditions.

GLP-1 Analogue 

CAS Number: 40077-57-4

Formula: C147H238N44O42S

Purchase

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Purpose Dosage Frequency
Neuroprotection .1-1mg daily Once daily
Immune Modulation .1-1mg daily Once daily

How It Works

VIP functions by binding to specific G-protein-coupled receptors (VPAC1 and VPAC2), triggering a cascade of cellular responses:

  • Promotes vasodilation, improving blood flow
  • Enhances neuroprotection by supporting neuronal survival
  • Modulates immune responses, reducing inflammation

Its broad activity across the nervous, cardiovascular, and immune systems positions VIP as a versatile peptide for research exploration.

 

Clinical Benefits

Vasodilation Support

  • Increases blood vessel relaxation, potentially aiding circulation
  • May assist in managing conditions linked to poor blood flow

Neuroprotection

  • Protects neurons from damage in preclinical models
  • Shows promise for neurodegenerative disease research

Immune Regulation

  • Reduces pro-inflammatory cytokines, balancing immune activity
  • Potential benefits in autoimmune and inflammatory conditions

Gastrointestinal Health

  • Supports smooth muscle relaxation in the gut
  • May improve digestive function and motility

Stress Response

  • Linked to calming effects via hypothalamic regulation
  • Could influence stress-related pathways

 

Dosage & Administration

  • Starting dose: 0.1 mg daily
  • Maintenance dose: Adjusted up to 1 mg daily, based on research protocols
  • Administration: Typically via subcutaneous injection or nasal spray

Always follow research guidelines or medical advice for dosing adjustments.

 

Where to Buy VIP

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Ongoing Research

  • Neurological Studies: Investigating VIP’s role in Alzheimer’s and Parkinson’s models
  • Cardiovascular Potential: Exploring benefits for hypertension and heart function
  • Immune Applications: Researching effects on chronic inflammation and autoimmunity
  • Long-Term Safety: Assessing prolonged use in various models
  • Delivery Optimization: Testing nasal vs. injectable administration efficacy

 

What is VIP (Vasoactive Intestinal Peptide) and How Does It Function?

VIP is a naturally occurring peptide hormone composed of 28 amino acids, found in various tissues including the gut, pancreas, and brain. It plays a crucial role in regulating smooth muscle activity, promoting vasodilation, stimulating secretion of water and electrolytes in the intestines, and modulating immune responses. VIP’s diverse functions make it significant in maintaining homeostasis across multiple organ systems.

VIP therapy has been explored for its potential benefits in various health conditions:​

  • Anti-Inflammatory Effects: VIP has shown promise in reducing inflammation, which may benefit individuals with autoimmune diseases and inflammatory conditions.

  • Respiratory Health: Due to its bronchodilatory properties, VIP may aid in managing respiratory conditions like asthma and chronic obstructive pulmonary disease (COPD). ​

  • Cardiovascular Support: VIP can induce vasodilation, potentially lowering blood pressure and improving blood flow, which may support heart health.

  • Neurological Benefits: VIP’s presence in the brain suggests it may play a role in neuroprotection and cognitive function, although more research is needed in this area.

VIP is commonly administered through subcutaneous injections or nasal sprays. The specific dosage and administration frequency depend on the individual’s health status and the condition being treated. It’s essential to follow a healthcare provider’s guidance for appropriate dosing.

 

While VIP therapy is generally well-tolerated, some individuals may experience side effects such as:​

  • Flushing or Warm Sensations: A feeling of warmth or redness in the skin.​

  • Headaches: Mild to moderate headaches may occur.​

  • Dizziness: Some users report lightheadedness.​

  • Heart Palpitations: An awareness of heartbeats or irregular heart rhythms.​

Due to its vasodilatory effects, VIP can lower blood pressure; therefore, individuals with hypotension or cardiovascular concerns should consult their healthcare provider before starting therapy.

Referenced Citations

  1. Bains, M., et al. (2019). Vasoactive Intestinal Peptide Deficiency Is Associated with Altered Gut Microbiota Communities in Male and Female C57BL/6 Mice. Frontiers in Microbiology, 10, 2689. https://doi.org/10.3389/fmicb.2019.02689

  2. Wikipedia Contributors. (2019, October 22). Vasoactive Intestinal Peptide. Wikipedia. Retrieved from https://en.wikipedia.org/wiki/Vasoactive_intestinal_peptide

  3. The Pancreapedia. (2015). Regulation of Pancreatic Secretion. The Pancreapedia: Exocrine Pancreas Knowledge Base. https://www.pancreapedia.org/reviews/regulation-of-pancreatic-secretion

  4. Riepl, R. L., et al. (1994). Effect of Intraduodenal Bile and Taurodeoxycholate on Exocrine Pancreatic Secretion and on Plasma Levels of Vasoactive Intestinal Polypeptide and Somatostatin in Man. Pancreas, 9(1), 109–116. https://doi.org/10.1097/00006676-199401000-00016

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